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Minggu, 29 September 2013

We share an ancestor who probably lived no more than 640 years ago

This post is a revised version of a previous post. The original post has been or will be deleted, with the comments preserved. Typically this is done with posts that attract many visits at the time they are published, and whose topics become particularly relevant or need to be re-addressed at a later date.

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We all evolved from one single-celled organism that lived billions of years ago. I don’t see why this is so hard for some people to believe, given that all of us also developed from a single fertilized cell in just 9 months.

However, our most recent common ancestor is not that first single-celled organism, nor is it the first Homo sapiens, or even the first Cro-Magnon.

The majority of the people who read this blog probably share a common ancestor who lived no more than 640 years ago. Genealogical records often reveal interesting connections - the figure below has been cropped from a larger one from Pinterest.


You and I, whoever you are, have each two parents. Each of our parents have (or had) two parents, who themselves had two parents. And so on.

If we keep going back in time, and assume that you and I do not share a common ancestor, there will be a point where the theoretical world population would have to be impossibly large.

Assuming a new generation coming up every 20 years, and going backwards in time, we get a theoretical population chart like the one below. The theoretical population grows in an exponential, or geometric, fashion.


As we move back in time the bars go up in size. Beyond a certain point their sizes go up so fast that you have to segment the chart. Otherwise the bars on the left side of the chart disappear in comparison to the ones on the right side (as several did on the chart above). Below is the section of the chart going back to the year 1371.


The year 1371 is a mere 640 years ago. And what is the theoretical population in that year if we assume that you and I have no common ancestors? The answer is: more than 8.5 billion people. We know that is not true.

Admittedly this is a somewhat simplistic view of this phenomenon, used here primarily to make a point. For example, it is possible that a population of humans became isolated 15 thousand years ago, remained isolated to the present day, and that one of their descendants just happened to be around reading this blog today.

Perhaps the most widely cited article discussing this idea is this one by Joseph T. Chang, published in the journal Advances in Applied Probability. For a more accessible introduction to the idea, see this article by Joe Kissell.

Estimates vary based on the portion of the population considered. There are also assumptions that have to be made based on migration and mating patterns, as well as the time for each generation to emerge and the stability of that number over time.

Still, most people alive today share a common ancestor who lived a lot more recently than they think. In most cases that common ancestor probably lived less than 640 years ago.

And who was that common ancestor? That person was probably a man who, due to a high perceived social status, had many consorts, who gave birth to many children. Someone like Genghis Khan.

Kamis, 12 September 2013

Good Affect with Mahometismo for The eu



Ottoman Empire begun capturing The eu around fourteenth 100 years through fifteenth 100 years have a lot of Eastern side The eu less than a empire. However microbes with Mahometismo are determined an extensive in advance of Ottoman Empire nonetheless Mahometismo blossomed effectively as soon as Ottoman Empire decided The eu. Historians will be of your mindset of which Mahometismo installed the walls of contemporary The eu and is particularly them point the. Track record includes recognized The eu major the modern world in earlier times many years thru a experience plus electricity but when most people analyze quick new technology with numbers, physics plus astronomy, and in addition; many of the credit ratings takes it to Islamic major scientific discipline. Islamic mathematicians been effective in just about every niche with numbers just like Al-Jabir established algebra. Galileo plus Newton, the actual truly amazing research workers of time, could not are qualified to develop elaborate website design practices with numbers plus physics not having the primary plus necessary methods manufactured by way of Islamic research workers.

Estudio plus Aristotle installed the exact body with conventional authoring plus messages around traditional The eu nevertheless écharpe were definitely displaced during the background were definitely just about doomed within the Shadowy Get older. That it was for a second time Muslims just who served because caretakers of such necessary writings plus ended up saving these folks. Quite possibly range that work appeared to be offer exclusively around Persia. Ibne-Rushd, women, also known as Averroes around The eu, have the identity in this regard.

Euro people will be recognized for their whole expeditions plus research but it surely appeared to be exclusively made easy because of the specific cartography that is generated by the exact Islamic mapmakers. Most of these cartography smooth the manner in which pertaining to Euro people to uncover innovative industrys around least life span.


This will only be the exact bit number of don expressed by Mahometismo that will The eu indirectly. Reported by world wide info, one can find related to 53 trillion Muslims around The eu. Mahometismo has been chosen as the swiftest raising croyance around The eu as well as around the world, there's been business of latest mosques all around The eu and non-Muslims will be viewing most of these mosques. The pace with change that will Mahometismo opportunity during the a short time in particular just after 9/11 disorders as soon as Muslims were definitely correspondent than me. That it was the amount of time as soon as non-Muslims in particular Christian believers were definitely even more intrigued to find out about the ins and outs of Mahometismo, Qura'an as well as theories with Holy Mystic (PBUH). However Mahometismo appeared to be inflated as a croyance with extremism plus terrorism however when these individuals learnt Mahometismo, their whole perspectives adjusted and determined Mahometismo as a accomplish style|code calculatordecoder|free codes|decoderdecoding|sstandards|regulations|unlock} with daily life as well as most effective croyance around the globe. So taken them just after their whole wide experiments. The exact Islamic foreigners with the Islamic earth that will The eu located now there for decades will be distinct designs with peaceful Islamic way of life.

Now multimedia, around The eu in particular, shares loads around the the exact disrespect presented to adult females around Mahometismo, employing point, it's not legitimate. Mahometismo is definitely the exclusively croyance with which has grown the exact high regard of girls derived from one of of your the wrong way embarrassed rodent, around North west way of life, to the next on the well intentioned simply being experiencing alike liberties that will dude. Below the improper ideological reasoning behind boy or girl union because of the non-Muslims, the exact Muslims are belittled because of the north west multimedia employing point there's no reasoning behind boy or girl union around Mahometismo and the like events will be totally restricted to very few good old customed tribes.

Many historians currently have disclosed Mahometismo as a history of contemporary The eu we expect who's are often the way forward for the exact Euro earth in addition.

Find the related info about islam through the Cerita Islami

Selasa, 10 September 2013

Inexpensive Company Cards Choices On the internet



Custom business cards are helpful small credit cards that have info concerning we rassemblement as well as our own company. Additionally they consist of our own title as well as tackle. When it comes to images, these people existing the organization logo design additionally. Many people print out additional information additionally on the custom business cards which can be necessary for all of them simply because they are part of a specific occupation. Custom business cards are in fact designed to act as memory space helps for individuals. Individuals might make reference to their own assortment of custom business cards once they wish to employ or even ask concerning the solutions provided by a specific person or perhaps a organization}. Custom business cards are often sold back whatsoever types of official events. These types of custom business cards had been imprinted within dark who else appeared great as well as notable upon white-colored papers however colour custom business cards would be the tradition nowadays.

Custom business cards are often imprinted upon thicker papers which could also generally be referred to as cards share. Top quality custom business cards tend to be imprinted by utilizing balance publishing methods. This really is carried out on the unique publishing push that needs preliminary preparing prior to the print out. Which means that it has an preliminary price attached with custom business cards that are imprinted employing this method. 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Minggu, 01 September 2013

Vegas bachelor party around animation- a good beginning on your qualified vocation




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Minggu, 25 Agustus 2013

Dr. Jekyll dieted and became Mr. Hyde

One of the most fascinating topics for an independent health researcher is the dichotomy between short- and long-term responses in successful dieters. In the short term, dieters that manage to lose a significant amount of fat mass, tend to feel quite well. Many report that their energy levels go through the roof.

A significant loss of fat mass could be considered one of 30 lbs, or 13.6 kg. This is the threshold for weight loss used in the National Weight Control Registry. Ideally you want to lose body fat, not lean mass, both of which contribute to weight loss.

So, in the short term, significant body fat loss feels pretty good for the dieters. In the long term, however, successful dieters tend to experience the symptoms of chronic stress. This should be no surprise because some of the same hormones that induce a sense of elation and high energy are the ones associated with chronic stress. These are generally referred to as “stress hormones”, of which the most prominent seem to be cortisol, epinephrine (adrenaline), and norepinephrine (noradrenaline).

Stress hormones display acute elevations during intense exercise as well ().

This is all consistent with evolution, and with the idea that our hominid ancestors would not go hungry for too long, at least not on a regular basis. High energy levels, combined with hunger, would make them succeed at hunting-gathering activities, leading to a period of feast before a certain threshold of sustained caloric restriction (with or without full fasting) would be reached. This would translate into a regular and cyclical hunger-feast process, with certain caloric costs having to be met for successful hunting-gathering.

After a certain period of time under sustained caloric restriction, it would probably be adaptive among our ancestors to experience significant mental and physical discomfort. That would compel our hominid ancestors to more urgently engaged in hunting-gathering activities.

And here is a big difference between those ancestors and modern urbanites: our ancestors would actually be working towards getting food for a feast, not restraining themselves from eating what they have easily available at home or from a grocery store nearby. There are major psychological differences here. Dieting, in the sense of not eating when food is easily available, is as unnatural as obesity, if not more.

So what are some of the mechanisms by which the body dials up stress, leading to the resulting mental and physical discomfort? Here is one that seems to play a key role: hypoglycemia.

Of the different types of hypoglycemia, there is one that is quite interesting in this type of context, because it refers to hypoglycemia in response to intake of any food item that raises insulin levels; that is, food that contains protein and/or carbohydrates. More specifically, we are referring here to reactive hypoglycemia, of the same general type as that experienced by those on their way to type II diabetes.

But reactive hypoglycemia in successful dieters is often different from that of prediabetics, as it is caused by something that would sound surprising to many: successful dieters appear to become too insulin sensitive for their own good!

There is ongoing debate as to what is considered a blood glucose level that is low enough to characterize hypoglycemia. Several factors influence that, including measurement method and age. One important factor related to measurement method is this: commercial fingerstick glucose meters tend to grossly underestimate low glucose levels (e.g., 50 mg/dl shows as 30 mg/dl).

Having said that, glucose levels below 60 mg/dl are generally considered low.

Luyckx and Lefebvre selected 47 cases of reactive hypoglycemia for a study, from a total of 663 standard four-hour oral glucose tolerance tests (OGTT). They classified these 47 cases as follows, with the number of cases in each class within parentheses: obesity (11), obesity with chemical diabetes (9), postgastrectomy syndrome (3), chemical diabetes without obesity (1), renal glycosuria (7), and isolated reactive hypoglycemia (16).

Postgastrectomy is the period following a gastrectomy, which is removal of part of one’s stomach. The modern term for this stomach amputation procedure is “bariatric surgery”; admittedly a broader term, which many people say they would do as if they were referring to a walk in the park!

In the cases of isolated reactive hypoglycemia, the individuals had normal weight, normal glucose tolerance, and no glycosuria (excretion of glucose in the urine). As you can see in the paragraph above, this, isolated reactive hypoglycemia, was the category with the largest number of individuals. The figure below illustrates what happened in these cases.


The cases in question are represented in the left part of the graph with dashed lines (the full lines are for normal controls). There a reasonably normal insulin response, lower in fact in terms of area under the curve (AUC) than for the controls, leads to an abnormal reduction in blood glucose levels. They are 9 out of 16, the majority of the isolated reactive hypoglycemia cases. In those 9 individuals, insulin became “more potent”, so to speak.

Reactive hypoglycemia is frequently associated with obesity, in which case it is also associated with hyperinsulinemia, and caused by an exaggerated insulin response. About 40 percent of the reactive hypoglycemia cases in the study were classified as happening in obese individuals.

This study suggests that, if you are not obese, and you are diagnosed with reactive hypoglycemia following an OGTT, chances are that the diagnosis is due to high insulin sensitivity – as opposed to low insulin sensitivity, coupled with hyperinsulinemia. A follow-up test should focus on insulin levels, to see if they are elevated; i.e., to try to detect hyperinsulinemia.

I have been blogging here long enough to hear from people who have gone the full fat2fit2fat cycle, sometimes more than once. They start dieting, go from obese to lean, feel good at first but then miserable, drop the diet, become obese or almost obese again, then start dieting again …

Quite a few are folks who do things like ditching industrial foods, regularly eating organ meats, and doing resistance exercise. How can you go wrong doing all of these, generally healthy, things? Well, they all increase your insulin sensitivity. If you don’t build in plateaus to slow down your progress, you may not give your body enough time to adapt.

You may become too lean, too fast, for your own good. The more successful the diet, the bigger is the risk. No wonder the paleo diet is being targeted lately as a “bad” diet. How can you go wrong on a diet of whole foods; “real” whole foods, not “whole wheat”? Well, here is how you can go wrong. The diet, if not managed properly, may be too successful for your own good; too much of a good thing can be a problem, you know!

See the graph below, from a previous post on a related topic (). I intend to discuss a method to identify the point at which weight loss should stop, in a future post. This method builds on the calculation of a simple index, which is unique to each individual. Let me just say now that I suspect that, with exceptions, frequently people are hurting their health by trying to have six pack abs.


But what does all this have to do with stress hormones? The connection is this. Hypoglycemia is only “felt”, as something unpleasant, due to the body’s frequent acute stress hormone response to it. Elevated levels of stress hormones also increase blood glucose levels, countering hypoglycemia. Our body’s priority is preventing hypoglycemia, not hyperglycemia ().

And here is an interesting pattern, based on anecdotal evidence from HCE () users. It seems that folks who have abnormally high insulin sensitivity, also have medium-to-high HbA1c (a measure of glycation) and fasting blood glucose levels. By medium-to-high HbA1c levels I mean 5.7 to even as high as 6.2.

Since cortisol is elevated, one would expect higher fasting blood glucose levels – the “dawn phenomenon”. But higher HbA1c, how? I am not sure, but I believe that HbA1c will be found in the future to be something a bit more complicated than what it is believed to be: a measure of average blood glucose over a period of time. I am not talking here about cases of anemia.

One indication of this complicated nature of the HbA1c is the fact that blood glucose levels in birds are high yet HbA1c levels are low, and birds live much longer than mammals of comparable size (). Some birds have extremely high glucose levels, even carnivorous birds who consume no or very small amounts of carbohydrate (e.g. hawks), with fairly low HbA1c levels.

The title of this post is inspired in the classic short novel “Strange Case of Dr. Jekyll and Mr. Hyde” by the Scottish author Robert Louis Stevenson; who also authored another famous novel, “Treasure Island”. In “Dr. Jekyll and Mr. Hyde”, gentle Dr. Jekyll becomes nasty Mr. Hyde (see poster below, from Wikipedia).


Mr. Hyde had a bad temper, impaired judgment, and was prone to criminal behavior. Hypoglycemia has long been associated with bad temper, impaired judgment, and criminal behavior (, ).

Kamis, 22 Agustus 2013

Could the low testosterone problem be a mirage?


Low testosterone (a.k.a. “low T”) is caused by worn out glands no longer able to secrete enough T, right? At least this seems to be the most prevalent theory today, a theory that reminds me a lot of the “tired pancreas” theory () of diabetes. I should note that this low T problem, as it is currently presented, is one that affects almost exclusively men, particularly middle-aged men, not women. This is so even though T plays an important role in women’s health.

There are many studies that show associations between T levels and all kinds of diseases in men. But here is a problem with hormones: often several hormones vary together and in a highly correlated fashion. If you rely on statistics to reach conclusions, you must use techniques that allow you to rule out confounders; otherwise you may easily reach wrong conclusions. Examples are multivariate techniques that are sensitive to Simpson’s paradox and nonlinear algorithms; both of which are employed, by the way, by modern software tools such as WarpPLS (). Unfortunately, these are rarely, if ever, used in health-related studies.

Many low T cases may actually be caused by something other than tired T-secretion glands, perhaps a hormone (or set of hormones) that suppress T production; a T “antagonist”. What would be a good candidate? The figure below shows two graphs. It is from a study by Starks and colleagues, published in the Journal of the International Society of Sports Nutrition in 2008 (). The study itself is not directly related to the main point that this post tries to make, but the figure is.



Look at the two graphs carefully. The one on the left is of blood cortisol levels. The one on the right is of blood testosterone levels. Ignore the variation within each graph. Just compare the two graphs and you will see one interesting thing – cortisol and testosterone levels are inversely related. This is a general pattern in connection with stress-induced cortisol elevations, repeating itself over and over again, whether the source of stress is mental (e.g., negative thoughts) or physical (e.g., intense exercise).

And the relationship between cortisol and testosterone is strong. Roughly speaking, an increase in cortisol levels, from about 20 to 40 μg/dl, appears to bring testosterone levels down from about 8 to 5 ηg/ml. A level of 8 ηg/ml (the same as 800 ηg/dl) is what is normally found in young men living in urban environments. A level of 5 ηg/ml is what is normally found in older men living in urban environments.

So, testosterone levels are practically brought down to almost half of what they were before by that variation in cortisol.

Chronic stress can easily bring your cortisol levels up to 40 μg/dl and keep them there. More serious pathological conditions, such as Cushing’s disease, can lead to sustained cortisol levels that are twice as high. There are many other things that can lead to chronically elevated cortisol levels. For instance, sustained calorie restriction raises cortisol levels, with a corresponding reduction in testosterone levels. As the authors of a study () of markers of semistarvation in healthy lean men note, grimly:

“…testosterone (T) approached castrate levels …”

The study highlights a few important phenomena that occur under stress conditions: (a) cortisol levels go up, and testosterone levels go down, in a highly correlated fashion (as mentioned earlier); and (b) it is very difficult to suppress cortisol levels without addressing the source of the stress. Even with testosterone administration, cortisol levels tend to be elevated.

Isn't possible that cortisol levels go up because testosterone levels go down - reverse causality? Possible, but unlikely. Evidence that testosterone administration may reduce cortisol levels, when it is found, tends to be rather weak or inconclusive. A good example is a study by Rubinow and colleagues (). Not only were their findings based on bivariate (or unadjusted) correlations, but also on a chance probability threshold that is twice the level usually employed in statistical analyses; the level usually employed is 5 percent.

Let us now briefly shift our attention to dieting. Dieting is the main source of calorie restriction in modern urban societies; an unnatural one, I should say, because it involves going hungry in the presence of food. Different people have different responses to dieting. Some responses are more extreme, others more mild. One main factor is how much body fat you want to lose (weight loss, as a main target, is a mistake); another is how low you expect body fat to get. Many men dream about six-pack abs, which usually require single-digit body fat percentages.

The type of transformation involving going from obese to lean is not “cost-free”, as your body doesn’t know that you are dieting. The body “sees” starvation, and responds accordingly.

Your body is a little bit like a computer. It does exactly what you “tell” it to do, but often not what you want it to do. In other words, it responds in relatively predictable ways to various diet and lifestyle changes, but not in the way that most of us want. This is what I call compensatory adaptation at work (). Our body often doesn’t respond in the way we expect either, because we don’t actually know how it adapts; this is especially true for long-term adaptations.

What initially feels like a burst of energy soon turns into something a bit more unpleasant. At first the unpleasantness takes the form of psychological phenomena, which were probably the “cheapest” for our bodies to employ in our evolutionary past. Feeling irritated is not as “expensive” a response as feeling physically weak, seriously distracted, nauseated etc. if you live in an environment where you don’t have the option of going to the grocery store to find fuel, and where there are many beings around that can easily kill you.

Soon the responses take the form of more nasty body sensations. Nearly all of those who go from obese to lean will experience some form of nasty response over time. The responses may be amplified by nutrient deficiencies. Obesity would have probably only been rarely, if ever, experienced by our Paleolithic ancestors. They would have never gotten obese in the first place. Going from obese to lean is as much a Neolithic novelty as becoming obese in the first place, although much less common.

And it seems that those who have a tendency toward mental disorders (e.g., generalized anxiety, manic-depression), even if at a subclinical level under non-dieting conditions, are the ones that suffer the most when calorie restriction is sustained over long periods of time. Most reports of serious starvation experiments (e.g., Roy Walford’s Biosphere 2 experiment) suggest the surfacing of mental disorders and even some cases of psychosis.

Emily Deans has a nice post () on starvation and mental health.

But you may ask: What if my low T problem is caused by aging; you just said that older males tend to have lower T? To which I would reply: Isn’t possible that the lower T levels normally associated with aging are in many cases a byproduct of higher stress hormone levels? Take a look at the figure below, from a study of age-related cortisol secretion by Zhao and colleagues ().



As you can see in the figure, cortisol levels tend to go up with age. And, interestingly, the range of variation seems very close to that in the earlier figure in this post, although I may be making a mistake in the conversion from nmol/l to ηg/ml. As cortisol levels go up, T levels should go down in response. There are outliers. Note the male outlier at the middle-bottom part, in his early seventies. He is represented by a filled circle, which refers to a disease-free male.

Dr. Arthur De Vany claims to have high T levels in his 70s. It is possible that he is like that outlier. If you check out De Vany’s writings, you’ll see his emphasis on leading a peaceful, stress-free, life (). If money, status, material things, health issues etc. are very important for you when you are young (most of us, a trend that seems to be increasing), chances are they are going to be a major source of stress as you age.

Think about individual property accumulation, as it is practiced in modern urban environments, and how unnatural and potentially stressful it is. Many people subconsciously view their property (e.g., a nice car, a bunch of shares in a publicly-traded company) as their extended phenotype. If that property is damaged or loses value, the subconscious mental state evoked is somewhat like that in response to a piece of their body being removed. This is potentially very stressful; a stress source that doesn’t go away easily. What we have here is very different from the types of stress that our Paleolithic ancestors faced.

So, what will happen if you take testosterone supplementation to solve your low T problem? If your problem is due to high levels of cortisol and other stress hormones (including some yet to be discovered), induced by stress, and your low T treatment is long-term, your body will adapt in a compensatory way. It will “sense” that T is now high, together with high levels of stress.

Whatever form long-term compensatory adaptation may take in this scenario, somehow the combination of high T and high stress doesn’t conjure up a very nice image. What comes to mind is a borderline insane person, possibly with good body composition, and with a lot of self-confidence – someone like the protagonist of the film American Psycho.

Again, will the high T levels, obtained through supplementation, suppress cortisol? It doesn’t seem to work that way, at least not in the long term. In fact, stress hormones seem to affect other hormones a lot more than other hormones affect them. The reason is probably that stress responses were very important in our evolutionary past, which would make any mechanism that could override them nonadaptive.

Today, stress hormones, while necessary for a number of metabolic processes (e.g., in intense exercise), often work against us. For example, serious conflict in our modern world is often solved via extensive writing (through legal avenues). Violence is regulated and/or institutionalized – e.g., military, law enforcement, some combat sports. Without these, society would break down, and many of us would join the afterlife sooner and more violently than we would like (see Pinker’s take on this topic: ).

Sir, the solution to your low T problem may actually be found elsewhere, namely in stress reduction. But careful, you run the risk of becoming a nice guy.